The MBRC is designed by members and founders of a sister initiative, the Exposure Therapy Consortium (ETC). With a similar structure, the ETC quickly grew to encompass over 125 members representing over 20 institutions. By the time the second study was proposed within the ETC, 16 sites across the world signed on to run the study within a 3-week bid period. The result is that this study is likely to be the largest exposure therapy mechanistic trial for anxiety ever conducted, while also providing the immediate strengths of cross-site and split sample replication of all findings. In sum, we have good evidence that programs like the ETC and MBRC can provide a dramatically successful research strategy for its collaborators and mechanistic science.